Amphotericin B is a low soluble broad-spectrum antifungal agent. Cyclodextrins can\nbe added to amphotericin formulations to enhance both their solubility and antifungal properties.\nSemisolid amphotericin formulations containing gamma cyclodextrin (AGCD) were prepared and\ncompared with two reference formulationsâ??one of them without any solubility enhancer (A)\nand the other with DMSO (ADMSO). Rheological, the permeability through hairless mouse skin\nand antifungal characteristics of the different formulations were evaluated. All three semisolid\nformulations show low thixotropy characteristics. ADMSO was the formulation with the least\nconsistency, lowest viscosity, and greatest extensibility. The AGCD formulation had the opposite\nbehavior and had both the greatest consistency and viscosity and the lowest extensibility. The lowest\npermeability was obtained with the reference A formulation while both AGCD and ADMSO had a\nsimilar permeability enhancement. According to the antimicrobial in vitro efficacy trials, the AGCD\nformulation showed 45â??60% more activity than the reference A formulation. It can be concluded thatâ?¦â?¦â?¦.
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